The ADVANCE (ArmeD SerVices TrAuma RehabilitatioN OutComE) study seeks to address these knowledge gaps in a contemporary population with CRTI. The relationship between CRTI and arterial stiffness has not been examined. 11 12 They were both retrospective and did not include an uninjured comparison group. Two recent studies have reported an association between CRTI and MetS. 9 10 Moreover, increased cAIx has been linked to all-cause mortality and MACE. However, there is increasing interest in central augmentation index (cAIx), which may be a more sensitive marker of early arterial stiffness and endothelial dysfunction. 7 8 Among the measures of arterial stiffness, pulse wave velocity (PWV) remains the gold standard. 6 MetS is associated with increased arterial stiffness and MACE. MetS affects up to 30% of Western adults, with a prevalence that is rapidly rising. Metabolic syndrome (MetS) and arterial stiffness are two recognised markers of cardiovascular risk. 4 There is a need for a contemporary prospective cohort study examining the relationship between CRTI and its severity to earlier markers of cardiovascular risk, which if established would prompt prevention strategies to mitigate the risk. 1–3 However, a recent systematic review and meta-analysis has shown that the strength of this evidence is modest, at best, and derived from retrospective studies relating to injuries sustained ≥40 years ago or from small cross-sectional studies with poorly defined control groups. It has been reported that severe CRTI may be associated with an increased risk of cardiovascular disease (CVD) and major adverse cardiovascular events (MACE). It does not store any personal data.The long-term health outcomes of survivors of combat-related traumatic injury (CRTI) are unclear. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance".
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